YH Cross CLAHRC Projects
Itchy Sneezy Wheezy
We have undertaken collaborative work with NIHR CLAHRC North West London on the Itchy Sneezy 
Wheezy project - a project to improve diagnosis and treatment of allergies, aiming to help children in Sheffield stay out of hospital. 130 patients attended 
an outreach clinic in a deprived area of Sheffield. The evaluation highlights a reduction in A&E attendances for this group of children.


Trials within Cohorts (TwiCs)
In November 2014 NIHR CLAHRC YH and NIHR CLAHRC North Thames hosted the ‘TwiCs’ symposium, the purpose was to advance the development and application of this design. This event brought together triallists with practical experience of the ‘TwiCs’ design; providing an opportunity for them to share with others what they have learnt about the practical, ethical and statistical aspects of the design.  The ‘cohort multiple RCT’ is one approach to the design and conduct of pragmatic trials within cohorts. The theoretical paper describing the design can be found here: www.bmj.com/content/340/bmj.c1066 After the success of the November 2014 symposium, the Wellcome Trust have provided £15,000 to conduct a further symposium in Autumn 2016 focusing on the ethics of the trial design. The symposium will provide an opportunity for trials and ethical experts to share their experience of the ‘TwiCs’ design with patients, clinicians and ethics boards. The objectives of the symposium are to share good practice, deliver a forum in which to discuss and debate ethical issues, and identify future directions for conceptual and empirical research.